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2022 NFL Week 2 Predictions
Updated: February 2024


Seattle Seahawks (0-1) at Detroit Lions (1-0) 1:00p (ET)
The Lions return home in Week 2 to face the Seahawks in what should be an absolutely frenetic environment. But the Lions are going to have to once again do their best work in the trenches to avoid getting run over by RB Kenneth Walker and the Seattle offense. One area that could be concerning for Seattle in this game is their secondary, considering that Matthew Stafford and the Rams’ passing game went for 334 yards in total. The Detroit Lions, with extended rest, will have a huge game in front of their fans and push the Seahawks to 0-2.

Date: Sunday - September 17th @ 1pm
Our Pick: Seahawks – 15, Lions - 23

Odds To Win: Lions -6 @ MyBookie Sportsbook


Indianapolis Colts (0-1) at Houston Texans (0-1) 1:00p (ET)
We have a battle of rookie QBs in the AFC South and two of the top four picks in this year’s NFL Draft: CJ Stroud of the Texans and Anthony Richardson of the Colts. And while Richardson had some big flashes in the Colts’ 10-point loss to the Jaguars in Week 1, the Ravens gave CJ Stroud a rude welcome to the NFL. The Colts and Texans both have new head coaches, so these are two teams in a developmental, transitional phase. This game could go either way but with the Texans playing at home, they should pull out a victory here.

Date: Sunday - September 17th @ 1pm
Our Pick: Colts – 18, Texans – 21

Odds To Win: Colts -1.5 @ MyBookie Sportsbook


New York Giants (0-1) at Arizona Cardinals (0-1) 4:05p (ET)
With both the Giants and the Cardinals coming off rough losses, this should be a very competitive matchup. The Cardinals had three solid quarters against the Commanders, going into the final quarter with a 16-10 lead. But were outscored 10-0 from there and lost 20-16. As terrible as the Giants looked against the Cowboys, this is as clear of a get-right game as you will have. This is not a high-powered offense that’s going to win in a lot of shootouts, but if they are able to dominate in the trenches and run the ball, they can be effective and win this game.

Date: Sunday - September 17th @ 4pm
Our Pick: Giants – 18, Cardinals - 17

Odds To Win: Giants -5.5 @ MyBookie Sportsbook


San Francisco 49ers (1-0) at Los Angeles Rams (1-0) 4:05p (ET)
With a 30-7 thumping in Pittsburgh, the 49ers notched probably the most impressive win of Week 1. Now, they will head back to California to face a more familiar opponent in the LA Rams, who look a bit different than they did last season. The Rams delivered an impressive offensive performance in Week 1 as well, against the Seahawks, and now look for their fifth 2-0 start in the last 6 years. This game might come down to which team can force more turnovers. The 49ers should come out on top in a closer game than most people expect.
Final Score:

Date: Sunday - September 17th @ 4pm
Our Pick: 49ers – 21, Rams - 20

Odds To Win: 49ers -8 @ MyBookie Sportsbook


New York Jets (1-0) at Dallas Cowboys (1-0) 4:25p (ET)
The Jets walked off on the Bills in overtime on a punt return touchdown by rookie Xavier Gipson. A huge victory at home for the Jets, but the bigger story of that game was the devastating loss of QB Aaron Rodgers. The future Hall of Famer ruptured his Achilles and will miss the rest of the season. Fresh off a dominant 40-0 thrashing of the New York Giants, the Cowboys are in an excellent position to start the season 2-0. The Jets defense will give Dallas a hard time, but with no Aaron Rodgers, it’s hard seeing the Jets win this game. And as long as the Cowboys don’t turn the ball over four or five times like the Bills did, they should win this one.

Date: Sunday - September 17th @ 4:25pm
Our Pick: Jets – 17, Cowboys – 24

Odds To Win: Cowboys -9.5 @ MyBookie Sportsbook


Cleveland Browns (1-0) at Pittsburgh Steelers (0-1) (Mon) 8:15p (ET)
How can anyone not be impressed with what the Cleveland Browns did on Sunday against the Bengals? Cincinnati got three points on the board, but it felt more like a shutout for the Browns defense, which was aggressive and suffocating all day long. I don’t know how much of a chance Steelers QB Kenny Pickett has in a matchup like this, especially after we witnessed the Steelers being driven into the ground by the 49ers. San Francisco sacked Pickett 5 times, and the Browns have a pass rush that is equally strong. The Steelers offense will have a tough game against this powerful Cleveland defense, which could get on a roll here to start the 2023 campaign.

Date: MNF - September 18th @ 8:15pm
Our Pick: Browns – 23, Steelers - 20

Odds To Win: Browns -2.5 @ MyBookie Sportsbook Sportsbook
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2023 NFL Football Season



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